Article
Targeted generation of DNA strand breaks using pyrene-conjugated triplex-forming oligonucleotides.
Biochemistry - 10 Jun 2008
Benfield Aaron P, Macleod Michael C, Liu Yaobin, Wu Qi, Wensel Theodore G, Vasquez Karen M
Abstract excerpt
Gene targeting by triplex-forming oligonucleotides (TFOs) has proven useful for gene modulation in vivo. Photoreactive molecules have been conjugated to TFOs to direct sequence-specific damage in double-stranded DNA. However, the photoproducts are often repaired efficiently in cells. This limitation has led to the search for sequence-specific photoreactive reagents that can produce more genotoxic lesions. Here we...
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