Mutational bias plays an important role in shaping longevity-related amino acid content in mammalian mtDNA-encoded proteins.

Abstract excerpt

During the course of evolution, amino acid shifts might have resulted in mitochondrial proteomes better endowed to resist oxidative stress. However, owing to the problem of distinguishing between functional constraints/adaptations in protein sequences and mutation-driven biases in the composition of these sequences, the adaptive value of such amino acid shifts remains under discussion. We have analyzed the coding...

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