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Article

The role of selection in the evolution of human mitochondrial genomes.

Genetics - 1 Jan 2006

Kivisild Toomas, Shen Peidong, Wall Dennis P, Do Bao, Sung Raphael, Davis Karen, Passarino Giuseppe, Underhill Peter A, Scharfe Curt, Torroni Antonio, Scozzari Rosaria, Modiano David, Coppa Alfredo, de Knijff Peter, Feldman Marcus, Cavalli-Sforza Luca L, Oefner Peter J

Abstract excerpt

High mutation rate in mammalian mitochondrial DNA generates a highly divergent pool of alleles even within species that have dispersed and expanded in size recently. Phylogenetic analysis of 277 human mitochondrial genomes revealed a significant (P < 0.01) excess of rRNA and nonsynonymous base substitutions among hotspots of recurrent mutation. Most hotspots involved transitions from guanine to adenine that, with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 16172508
DOI: 10.1534/genetics.105.043901
PMCID: PMC1456165

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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