Article

Pathogenic amino acids in mitochondrial proteins more frequently arise in lineages closely related to human than in distant lineages

2017-09-27

Abstract excerpt

Propensities for different amino acids within a protein site change in the course of evolution, so that an amino acid deleterious in a particular species may be acceptable at the same site in a different species. Here, we study the amino acid-changing variants in human mitochondrial genes, and analyze their occurrence in non-human species. We show that substitutions giving rise to the human amino acid variant tend...

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Literature Corpus work: 2e164cba-c923-5a4c-b64b-66df1a3fe992
DOI: 10.7287/peerj.preprints.3211v2

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