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Article

SMC complexes are guarded by the SUMO protease Ulp2 against SUMO-chain-mediated turnover.

Cell reports - 3 Aug 2021

Psakhye Ivan, Branzei Dana

Abstract excerpt

Structural maintenance of chromosomes (SMCs) complexes, cohesin, condensin, and Smc5/6, are essential for viability and participate in multiple processes, including sister chromatid cohesion, chromosome condensation, and DNA repair. Here we show that SUMO chains target all three SMC complexes and are antagonized by the SUMO protease Ulp2 to prevent their turnover. We uncover that the essential role of the...

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Identifiers

PMID: 34348159
DOI: 10.1016/j.celrep.2021.109485

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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