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Article

Sumoylation and the structural maintenance of chromosomes (Smc) 5/6 complex slow senescence through recombination intermediate resolution.

The Journal of biological chemistry - 16 Apr 2010

Chavez Alejandro, George Vanessa, Agrawal Vishesh, Johnson F Brad

Abstract excerpt

Telomeres are repetitive nucleoprotein structures that cap the ends of chromosomes. Without telomerase, telomeres shorten with replication and eventually signal cell cycle arrest (cell senescence). Homologous recombination (HR)-based mechanisms slow senescence, and distinct HR mechanisms support...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Processing, Post-Translational

Share to Small Ubiquitin-Related Modifier Proteins

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Source

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Identifiers

PMID: 20159973
DOI: 10.1074/jbc.M109.041277
PMCID: PMC2852929

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20159973-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Sumoylation and the structural maintenance of chromosomes (Smc) 5/6 complex slow senescence through recombination intermediate resolution.PMID 20159973Read ↗

Evidence that the S.cerevisiae Sgs1 protein facilitates recombinational repair of telomeres during senescence.Semantic proximity Read ↗

Abrupt telomere losses and reduced end-resection can explain accelerated senescence of Smc5/6 mutants lacking telomerase.Semantic proximity Read ↗

Role of SUMO in the dynamics of telomere maintenance in fission yeast.Semantic proximity Read ↗

The Saccharomyces cerevisiae Esc2 and Smc5-6 proteins promote sister chromatid junction-mediated intra-S repair.Semantic proximity Read ↗

Sumoylation of the BLM ortholog, Sgs1, promotes telomere–telomere recombination in budding yeastSemantic proximity Read ↗

The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast.Semantic proximity Read ↗

Chromatin modifiers and recombination factors promote a telomere fold-back structure, that is lost during replicative senescenceSemantic proximity Read ↗

Histone Modifications and the Maintenance of Telomere IntegritySemantic proximity Read ↗

Evidence that a RecQ helicase slows senescence by resolving recombining telomeres.Semantic proximity Read ↗

Smc5/6 maintains stalled replication forks in a recombination-competent conformation.Semantic proximity Read ↗

Sgs1's roles in DNA end resection, HJ dissolution, and crossover suppression require a two-step SUMO regulation dependent on Smc5/6.Semantic proximity Read ↗

Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescenceSemantic proximity Read ↗

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