Article
Genome wide association study of age at menarche in the Japanese population.
PloS one - 1 Jan 2013
Tanikawa Chizu, Okada Yukinori, Takahashi Atsushi, Oda Katsutoshi, Kamatani Naoyuki, Kubo Michiaki, Nakamura Yusuke, Matsuda Koichi
Abstract excerpt
Age at menarche (AAM) is a complex trait involving both genetic and environmental factors. To identify the genetic factors associated with AAM, we conducted a large-scale meta-analysis of genome-wide association studies using more than 15,000 Japanese female samples. Here, we identified an association between SNP (single nucleotide polymorphism) rs364663 at the LIN28B locus and AAM, with a P-value of 5.49×10(-7)...
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