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Article

Bivariate genome-wide linkage analysis for traits BMD and AAM: effect of menopause on linkage signals.

Maturitas - 20 Jan 2009

Zhang Zhi-Xin, Lei Shu-Feng, Deng Fei-Yan, Zhang Feng, Liu Yong-Jun, Recker Robert R, Papasian Christopher J, Deng Hong-Wen

Abstract excerpt

Osteoporosis is an age-related systemic skeletal disease, characterized by low bone mineral density (BMD). Low BMD is closely associated with late age at menarche (AAM). Our previous bivariate genome-wide linkage analyses (GWLAs) between BMD and AAM identified two shared genomic regions in 2584 Caucasian females including both pre- and post-menopausal females. However, menopause often causes dramatic bone loss in...

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Bone Density
Exostosin 1
Genetic Linkage
Menarche
N-Acetylglucosaminyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 19019586
DOI: 10.1016/j.maturitas.2008.10.001

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