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Article

Arachidonate 5-lipoxygenase gene variants affect response to fish oil supplementation by healthy African Americans.

The Journal of nutrition - 1 Aug 2012

Armstrong Patrice, Kelley Darshan S, Newman John W, Staggers Frank E, Hartiala Janna, Allayee Hooman, Stephensen Charles B

Abstract excerpt

Arachidonate 5-lipoxygenase (ALOX5) gene variants that are common in people of African ancestry are associated with a differential cardiovascular disease (CVD) risk that may be ameliorated by intake of (n-3) PUFA, such as EPA or DHA. We conducted a double-masked, placebo (PL)-controlled trial of fish oil (FO) supplements to determine if changes in erythrocyte (n-3) PUFA composition, heart rate, blood pressure,...

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Source

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Identifiers

PMID: 22739369
DOI: 10.3945/jn.112.159814
PMCID: PMC3397335

Genes

ALOX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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