Article
Interaction between BMI and APOE genotype is associated with changes in the plasma long-chain-PUFA response to a fish-oil supplement in healthy participants.
The American journal of clinical nutrition - 1 Aug 2015
Chouinard-Watkins Raphaël, Conway Valérie, Minihane Anne M, Jackson Kim G, Lovegrove Julie A, Plourde Mélanie
Abstract excerpt
BACKGROUND: Carriers of the apolipoprotein E ɛ4 (APOE4) allele are lower responders to a docosahexaenoic acid (DHA) supplement than are noncarriers. This effect could be exacerbated in overweight individuals because DHA metabolism changes according to body mass index (BMI; in kg/m²). OBJECTIVES: We evaluated the plasma fatty acid (FA) response to a DHA-rich supplement in APOE4 carriers and noncarriers consuming a...
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