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Article

Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis.

The New England journal of medicine - 1 Jan 2004

Dwyer James H, Allayee Hooman, Dwyer Kathleen M, Fan Jing, Wu Huiyun, Mar Rebecca, Lusis Aldons J, Mehrabian Margarete

Abstract excerpt

BACKGROUND: Leukotrienes are inflammatory mediators generated from arachidonic acid (polyunsaturated n-6 fatty acid) by the enzyme 5-lipoxygenase. Since atherosclerosis involves arterial inflammation, we hypothesized that a polymorphism in the 5-lipoxygenase gene promoter could relate to atherosc...

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Identifiers

PMID: 14702425
DOI: 10.1056/NEJMoa025079

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14702425-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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