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Article

A multi-level gene-diet interaction analysis of fish oil and 14 polyunsaturated fatty acid traits identifies the FADS and GPR12 loci.

HGG advances - 10 Jul 2025

Ihejirika Susan Adanna, Chiang Alexandra Huong, Singh Aryaman, Stephen Eunice, Chen Han, Ye Kaixiong

Abstract excerpt

Fish oil supplements (FOS) are known to alter circulating levels of polyunsaturated fatty acids (PUFAs) but in a heterogeneous manner across individuals. These varied responses may result from unidentified gene-FOS interactions. To identify genetic factors that interact with FOS to alter the circulating levels of PUFAs, we performed a multi-level genome-wide interaction study (GWIS) of FOS on 14 plasma...

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Source

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Identifiers

PMID: 40405463
DOI: 10.1016/j.xhgg.2025.100459
PMCID: PMC12172259

Genes

FOS
FADS1
FADS2
GPR12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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