Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.

doi:10.1161/CIRCGENETICS.113.000208

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Article

Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.

Circulation. Cardiovascular genetics - 1 Jun 2014

Guan Weihua, Steffen Brian T, Lemaitre Rozenn N, Wu Jason H Y, Tanaka Toshiko, Manichaikul Ani, Foy Millennia, Rich Stephen S, Wang Lu, Nettleton Jennifer A, Tang Weihong, Gu Xiangjun, Bandinelli Stafania, King Irena B, McKnight Barbara, Psaty Bruce M, Siscovick David, Djousse Luc, Chen Yii-Der Ida, Ferrucci Luigi, Fornage Myriam, Mozafarrian Dariush, Tsai Michael Y, Steffen Lyn M

Abstract excerpt

BACKGROUND: Omega6 (n6) polyunsaturated fatty acids (PUFAs) and their metabolites are involved in cell signaling, inflammation, clot formation, and other crucial biological processes. Genetic components, such as variants of fatty acid desaturase (FADS) genes, determine the composition of n6 PUFAs. METHODS AND RESULTS: To elucidate undiscovered biological pathways that may influence n6 PUFA composition, we...

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Identifiers

PMID: 24823311
DOI: 10.1161/CIRCGENETICS.113.000208
PMCID: PMC4123862

Genes

GLA
AGPAT1
NRBF2
NTAN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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