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2,6-Dithiopurine, a nucleophilic scavenger, protects against mutagenesis in mouse skin treated in vivo with 2-(chloroethyl) ethyl sulfide, a mustard gas analog.

Toxicology and applied pharmacology - 1 Sept 2012

Boulware Stephen, Fields Tammy, McIvor Elizabeth, Powell K Leslie, Abel Erika L, Vasquez Karen M, MacLeod Michael C

Abstract excerpt

Sulfur mustard [bis(2-chloroethyl)sulfide, SM] is a well-known DNA-damaging agent that has been used in chemical warfare since World War I, and is a weapon that could potentially be used in a terrorist attack on a civilian population. Dermal exposure to high concentrations of SM produces severe, long-lasting burns. Topical exposure to high concentrations of 2-(chloroethyl) ethyl sulfide (CEES), a monofunctional...

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Identifiers

PMID: 22732900
DOI: 10.1016/j.taap.2012.06.010
PMCID: PMC3422404

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