Article
Somatic-cell mutation induced by short exposures to cigarette smoke in urate-null, oxidative stress-sensitive Drosophila.
Mutagenesis - 1 Jan 2016
Uchiyama Tomoyo, Koike Ryota, Yuma Yoko, Okamoto Keinosuke, Arimoto-Kobayashi Sakae, Suzuki Toshinori, Negishi Tomoe
Abstract excerpt
We previously reported that a urate-null strain of Drosophila is hypersensitive to cigarette smoke (CS), and we suggested that CS induces oxidative stress in Drosophila because uric acid is a potent antioxidant. Although the carcinogenic risk of CS exposure is widely recognized; documentation of in vivo genotoxic activity of environmental CS, especially gaseous-phase CS, remains inconclusive. To date,...
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