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Article

Absence of a p53 allele delays nitrogen mustard-induced early apoptosis and inflammation of murine skin.

Toxicology - 15 Sept 2013

Inturi Swetha, Tewari-Singh Neera, Jain Anil K, Roy Srirupa, White Carl W, Agarwal Rajesh

Abstract excerpt

Bifunctional alkylating agent sulfur mustard (SM) and its analog nitrogen mustard (NM) cause DNA damage leading to cell death, and potentially activating inflammation. Transcription factor p53 plays a critical role in DNA damage by regulating cell cycle progression and apoptosis. Earlier studies by our laboratory demonstrated phosphorylation of p53 at Ser15 and an increase in total p53 in epidermal cells both in...

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Identifiers

PMID: 23845566
DOI: 10.1016/j.tox.2013.06.013
PMCID: PMC3808076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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