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Article

Analysis of in vivo mutation in the Hprt and Tk genes of mouse lymphocytes.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2014

Dobrovolsky Vasily N, Shaddock Joseph G, Heflich Robert H

Abstract excerpt

Assays measuring mutant frequencies in endogenous reporter genes are used for identifying potentially genotoxic environmental agents and discovering phenotypes prone to genomic instability and diseases, such as cancer. Here, we describe methods for identifying mouse spleen lymphocytes with mutations in the endogenous X-linked hypoxanthine guanine phosphoribosyl transferase (Hprt) gene and the endogenous autosomal...

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Identifiers

PMID: 24623234
DOI: 10.1007/978-1-62703-739-6_20

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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