Article
Gpt delta transgenic mouse: a novel approach for molecular dissection of deletion mutations in vivo.
Advances in biophysics - 1 Jan 2004
Nohmi Takehiko, Masumura Ken-Ichi
Abstract excerpt
Human genome is continuously exposed to various DNA damaging agents including reactive oxygen species. Of various forms of DNA damage, double-strand breaks (DSBs) in DNA are the most detrimental because of the mutagenicity and cytotoxicity. To combat the serious threats posed by DSBs, cells evolved various homologous and non-homologous recombination repair mechanisms. However, some repair mechanisms appear to be...
Topics
- Animals
- Bone Marrow
- Cell Transformation, Neoplastic
- Colon
- DNA Damage
- DNA-Activated Protein Kinase
- DNA-Binding Proteins
- Escherichia coli Proteins
- Gene Deletion
- Humans
- Imidazoles
- Liver
- Mice
- Mice, Transgenic
- Mitomycin
- Mutagenesis
- Mutagenicity Tests
- Mutation