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Article

Analysis of In Vivo Mutation in the Hprt and Tk Genes of Mouse Lymphocytes.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020

Dobrovolsky Vasily N, Shaddock Joseph G, Heflich Robert H

Abstract excerpt

Determining mutant frequencies in endogenous reporter genes is a tool for identifying potentially genotoxic environmental agents, and discovering phenotypes prone to genomic instability and diseases, such as cancer. Here, we describe a high-throughput method for identifying mouse spleen lymphocytes with mutations in the endogenous X-linked hypoxanthine guanine phosphoribosyl transferase (Hprt) gene and the...

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PMID: 31989565
DOI: 10.1007/978-1-0716-0223-2_19

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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