Article
Topical DNA oligonucleotide therapy reduces UV-induced mutations and photocarcinogenesis in hairless mice.
Proceedings of the National Academy of Sciences of the United States of America - 16 Mar 2004
Goukassian David A, Helms Elizabeth, van Steeg Harry, van Oostrom Conny, Bhawan Jag, Gilchrest Barbara A
Abstract excerpt
UV-induced DNA damage gives rise to mutations and skin cancer. We have previously reported that treatment of skin cells in vitro with thymidine dinucleotide (pTT) activates p53 and increases the ability of cells to repair subsequent UV-induced DNA damage by enhancing endogenous DNA repair capacity. Here we show that topical pTT pretreatment enhances the rate of DNA photoproduct removal, decreases UV-induced...
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