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Article

Sulforaphane induces phase II detoxication enzymes in mouse skin and prevents mutagenesis induced by a mustard gas analog.

Toxicology and applied pharmacology - 1 Feb 2013

Abel E L, Boulware S, Fields T, McIvor E, Powell K L, DiGiovanni J, Vasquez K M, MacLeod M C

Abstract excerpt

Mustard gas, used in chemical warfare since 1917, is a mutagenic and carcinogenic agent that produces severe dermal lesions for which there are no effective therapeutics; it is currently seen as a potential terrorist threat to civilian populations. Sulforaphane, found in cruciferous vegetables, is known to induce enzymes that detoxify compounds such as the sulfur mustards that react through electrophilic...

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Identifiers

PMID: 23201461
DOI: 10.1016/j.taap.2012.11.020
PMCID: PMC3804329

Genes

GSTA4

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