The frequency of Pig-a mutant red blood cells in rats exposed in utero to N-ethyl-N-nitrosourea.

doi:10.1002/em.21704

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Article

The frequency of Pig-a mutant red blood cells in rats exposed in utero to N-ethyl-N-nitrosourea.

Environmental and molecular mutagenesis - 1 Jul 2012

Dobrovolsky Vasily N, Heflich Robert H, Ferguson Sherry A

Abstract excerpt

The Pig-a assay has been developed as a rapid sensitive measure of gene mutation in adult rats; however, no data exist on its ability to detect mutation following in utero exposures or in neonatal animals. Pregnant Sprague-Dawley rats were treated daily on gestational days 12-18 with oral doses of 0, 6, or 12 mg/kg/day N-ethyl-N-nitrosourea (ENU); following parturition, the offspring and dams were monitored over...

Topics

Alkylating Agents
Animals
CD59 Antigens
Erythrocytes
Ethylnitrosourea
Female
Membrane Proteins
Mutagenicity Tests
Mutagens
Mutation
Pregnancy
Prenatal Exposure Delayed Effects
Rats
Rats, Sprague-Dawley
Uterus

Source

Open in PubMed

Identifiers

PMID: 22730214
DOI: 10.1002/em.21704

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