Article
Common variants at ten loci influence QT interval duration in the QTGEN Study.
Nature genetics - 1 Apr 2009
Newton-Cheh Christopher, Eijgelsheim Mark, Rice Kenneth M, de Bakker Paul I W, Yin Xiaoyan, Estrada Karol, Bis Joshua C, Marciante Kristin, Rivadeneira Fernando, Noseworthy Peter A, Sotoodehnia Nona, Smith Nicholas L, Rotter Jerome I, Kors Jan A, Witteman Jacqueline C M, Hofman Albert, Heckbert Susan R, O'Donnell Christopher J, Uitterlinden André G, Psaty Bruce M, Lumley Thomas, Larson Martin G, Stricker Bruno H Ch
Abstract excerpt
QT interval duration, reflecting myocardial repolarization on the electrocardiogram, is a heritable risk factor for sudden cardiac death and drug-induced arrhythmias. We conducted a meta-analysis of three genome-wide association studies in 13,685 individuals of European ancestry from the Framingham Heart Study, the Rotterdam Study and the Cardiovascular Health Study, as part of the QTGEN consortium. We observed...
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