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Article

Activity-dependent growth of new dendritic spines is regulated by the proteasome.

Neuron - 21 Jun 2012

Hamilton Andrew M, Oh Won Chan, Vega-Ramirez Hugo, Stein Ivar S, Hell Johannes W, Patrick Gentry N, Zito Karen

Abstract excerpt

Growth of new dendritic spines contributes to experience-dependent circuit plasticity in the cerebral cortex. Yet the signaling mechanisms leading to new spine outgrowth remain poorly defined. Increasing evidence supports that the proteasome is an important mediator of activity-dependent neuronal signaling. We therefore tested the role of the proteasome in activity-dependent spinogenesis. Using pharmacological...

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Source

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Identifiers

PMID: 22726833
DOI: 10.1016/j.neuron.2012.04.031
PMCID: PMC3500563

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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