Article

Tau regulates Arc stability in neuronal dendrites via a proteasome-sensitive but ubiquitin-independent pathway

2022-12-15

Abstract excerpt

Tauopathies are neurodegenerative disorders characterized by the deposition of aggregates of the microtubule associated protein tau, a main component of neurofibrillary tangles. Alzheimer’s disease (AD) is the most common type of tauopathy and dementia, with amyloid-beta pathology as an additional hallmark feature of the disease. Besides the role of tau in stabilizing microtubules, it is localized at postsynaptic...

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Literature Corpus work: 261c9e4b-a9f3-5a1c-bddb-72aa3c87928c
DOI: 10.1101/2022.12.15.520620

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