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Article

SPIN90 dephosphorylation is required for cofilin-mediated actin depolymerization in NMDA-stimulated hippocampal neurons.

Cellular and molecular life sciences : CMLS - 1 Nov 2013

Cho In Ha, Lee Min Jung, Kim Dae Hwan, Kim Bora, Bae Jeomil, Choi Kyu Yeong, Kim Seon-Myung, Huh Yun Hyun, Lee Kun Ho, Kim Chong-Hyun, Song Woo Keun

Abstract excerpt

Actin plays a fundamental role in the regulation of spine morphology (both shrinkage and enlargement) upon synaptic activation. In particular, actin depolymerization is crucial for the spine shrinkage in NMDAR-mediated synaptic depression. Here, we define the role of SPIN90 phosphorylation/dephosphorylation in regulating actin depolymerization via modulation of cofilin activity. When neurons were treated with...

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Identifiers

PMID: 23765104
DOI: 10.1007/s00018-013-1391-4
PMCID: PMC3825632

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