Ubiquitin-mediated proteasome activity is required for agonist-induced endocytosis of GluRs.

Abstract excerpt

Recent studies documenting a role for local protein synthesis in synaptic plasticity have lead to interest in the opposing process, protein degradation, as a potential regulator of synaptic function. The ubiquitin-conjugation system identifies, modifies, and delivers proteins to the proteasome for degradation. We found that both the proteasome and ubiquitin are present in the soma and dendrites of hippocampal...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cysteine Proteinase Inhibitors
• Share to Endocytosis
• Share to Hippocampus