Article

Calmodulin variants in schizophrenia patients display gain-of-function or loss-of-function effects

2024-05-22

Abstract excerpt

Calmodulin acts as a vital calcium sensor in cells, crucial for relaying calcium signals to different protein partners. While rare missense variants in calmodulin are linked to cardiac arrhythmia, particularly long QT syndrome (LQTS), their role in schizophrenia remains unexplored. We investigated missense variants in the calmodulin-encoding genes CALM1-3 in a large-scale sequencing effort involving 24,248 schizop...

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Literature Corpus work: aa64ee4f-8fa1-53ce-bc33-91b2f6df1d49
DOI: 10.1101/2024.05.22.24307674

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