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Article

From Gene to Behavior: L-Type Calcium Channel Mechanisms Underlying Neuropsychiatric Symptoms.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics - 1 Jul 2017

Kabir Zeeba D, Martínez-Rivera Arlene, Rajadhyaksha Anjali M

Abstract excerpt

The L-type calcium channels (LTCCs) Cav1.2 and Cav1.3, encoded by the CACNA1C and CACNA1D genes, respectively, are important regulators of calcium influx into cells and are critical for normal brain development and plasticity. In humans, CACNA1C has emerged as one of the most widely reproduced and prominent candidate risk genes for a range of neuropsychiatric disorders, including bipolar disorder (BD),...

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Identifiers

PMID: 28497380
DOI: 10.1007/s13311-017-0532-0
PMCID: PMC5509628

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