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Article

CACNA1C-Related Channelopathies.

Handbook of experimental pharmacology - 1 Jan 2023

Herold Kevin G, Hussey John W, Dick Ivy E

Abstract excerpt

The CACNA1C gene encodes the pore-forming subunit of the CaV1.2 L-type Ca2+ channel, a critical component of membrane physiology in multiple tissues, including the heart, brain, and immune system. As such, mutations altering the function of these channels have the potential to impact a wide array of cellular functions. The first mutations identified within CACNA1C were shown to cause a severe, multisystem...

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Identifiers

PMID: 36598608
DOI: 10.1007/164_2022_624
PMCID: PMC10576998

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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