Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.

doi:10.1016/j.ajhg.2012.05.009

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.

American journal of human genetics - 13 Jul 2012

Tang Weihong, Schwienbacher Christine, Lopez Lorna M, Ben-Shlomo Yoav, Oudot-Mellakh Tiphaine, Johnson Andrew D, Samani Nilesh J, Basu Saonli, Gögele Martin, Davies Gail, Lowe Gordon D O, Tregouet David-Alexandre, Tan Adrian, Pankow James S, Tenesa Albert, Levy Daniel, Volpato Claudia B, Rumley Ann, Gow Alan J, Minelli Cosetta, Yarnell John W G, Porteous David J, Starr John M, Gallacher John, Boerwinkle Eric, Visscher Peter M, Pramstaller Peter P, Cushman Mary, Emilsson Valur, Plump Andrew S, Matijevic Nena, Morange Pierre-Emmanuel, Deary Ian J, Hicks Andrew A, Folsom Aaron R

Abstract excerpt

Activated partial thromboplastin time (aPTT) and prothrombin time (PT) are clinical tests commonly used to screen for coagulation-factor deficiencies. One genome-wide association study (GWAS) has been reported previously for aPTT, but no GWAS has been reported for PT. We conducted a GWAS and meta-analysis to identify genetic loci for aPTT and PT. The GWAS for aPTT was conducted in 9,240 individuals of European...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cohort Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Profiling

Share to Genome-Wide Association Study

Share to Partial Thromboplastin Time

Share to Prothrombin Time

Share to Risk

Share to Thromboembolism

Share to Thrombosis

Source

Open in PubMed Open full text

Identifiers

PMID: 22703881
DOI: 10.1016/j.ajhg.2012.05.009
PMCID: PMC3397273

Genes

ABO
CAD
AGBL1
EDEM2
HRG
KNG1
PROCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.PMID 22703881Read ↗

A genetic association study of activated partial thromboplastin time in European Americans and African Americans: the ARIC Study.Semantic proximity Read ↗

Common variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin time.Semantic proximity Read ↗

Antithrombin, Protein C, and Protein S: Genome and Transcriptome-Wide Association Studies Identify 7 Novel Loci Regulating Plasma Levels.Semantic proximity Read ↗

A gene-centric analysis of activated partial thromboplastin time and activated protein C resistance using the HumanCVD focused genotyping array.Semantic proximity Read ↗

Genetics of arterial prothrombotic risk states.Semantic proximity Read ↗

Genetic assessment of efficacy and safety profiles of coagulation cascade proteins identifies Factors II and XI as actionable anticoagulant targetsSemantic proximity Read ↗

Genetic variation within the anticoagulant, procoagulant, fibrinolytic and innate immunity pathways as risk factors for venous thromboembolism.Semantic proximity Read ↗

Application of Human Genetics to Prioritize Coagulation Cascade Protein Targets for Ischemic Stroke PreventionSemantic proximity Read ↗

Associations Between Common and Rare Exonic Genetic Variants and Serum Levels of 20 Cardiovascular-Related Proteins: The Tromsø Study.Semantic proximity Read ↗

Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.Semantic proximity Read ↗

Associations of activated coagulation factor VII and factor VIIa-antithrombin levels with genome-wide polymorphisms and cardiovascular disease risk.Semantic proximity Read ↗

Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.