Article
Common variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin time.
American journal of human genetics - 9 Apr 2010
Houlihan Lorna M, Davies Gail, Tenesa Albert, Harris Sarah E, Luciano Michelle, Gow Alan J, McGhee Kevin A, Liewald David C, Porteous David J, Starr John M, Lowe Gordon D, Visscher Peter M, Deary Ian J
Abstract excerpt
Activated partial thromboplastin time (aPTT) is associated with risk of thrombosis and coagulation disorders. We conducted a genome-wide association study for aPTT and identified significant associations with SNPs in three coagulation cascade genes, F12 (rs2731672, combined p = 2.16 x 10(-30)), KNG1 (rs710446, combined p = 9.52 x 10(-22)), and HRG (rs9898, combined p = 1.34 x 10(-11)). These three SNPs explain...
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