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Article

A gene-centric analysis of activated partial thromboplastin time and activated protein C resistance using the HumanCVD focused genotyping array.

European journal of human genetics : EJHG - 1 Jul 2013

Gaunt Tom R, Lowe Gordon D O, Lawlor Debbie A, Casas Juan-Pablo, Day Ian N M

Abstract excerpt

Activated partial thromboplastin time (aPTT) is an important routine measure of intrinsic blood coagulation. Addition of activated protein C (APC) to the aPTT test to produce a ratio, provides one measure of APC resistance. The associations of some genetic mutations (eg, factor V Leiden) with these measures are established, but associations of other genetic variations remain to be established. The objective of...

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Source

Open in PubMed Open full text

Identifiers

PMID: 23188048
DOI: 10.1038/ejhg.2012.242
PMCID: PMC3682876

Genes

APC
HRG
ABO
GRK6
KLKB1
KNG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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