Article
Association of functional catechol O-methyl transferase (COMT) Val108Met polymorphism with smoking severity and age of smoking initiation in Chinese male smokers.
Psychopharmacology - 1 Mar 2007
Guo Song, Chen Da Fang, Zhou Dong Feng, Sun Hong Qiang, Wu Gui Ying, Haile Colin N, Kosten Therese A, Kosten Thomas R, Zhang Xiang Yang
Abstract excerpt
RATIONALE: Catechol-O-methyltransferase (COMT) is an enzyme involved in the degradation and inactivation of the neurotransmitter dopamine, which is important in mediating drug reward such as nicotine in tobacco smoke. Different COMT alleles encode enzyme whose activity varies from three- to fourfold that may affect dopamine levels and alter subjective effects of nicotine. Recent evidence also suggests that a COMT...
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