Variants in COMT and spontaneous smoking cessation: retrospective cohort analysis of 925 cessation events.

doi:10.1097/FPC.0b013e32832fabf3

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Article

Variants in COMT and spontaneous smoking cessation: retrospective cohort analysis of 925 cessation events.

Pharmacogenetics and genomics - 1 Aug 2009

Breitling Lutz Philipp, Dahmen Norbert, Illig Thomas, Rujescu Dan, Nitz Barbara, Raum Elke, Winterer Georg, Rothenbacher Dietrich, Brenner Hermann

Abstract excerpt

Genome-wide studies have identified single nucleotide polymorphisms associated with smoking behaviour and nicotine dependence. Less is known about genetic determinants of smoking cessation, but rs4680 in COMT has recently been shown to explain a substantial proportion of the variation in cessation in the general population. We attempted to replicate the reported, clinically relevant effect in a population-based...

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PMID: 19584770
DOI: 10.1097/FPC.0b013e32832fabf3

Genes

COMT

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