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Article

Catechol-O-methyltransferase (COMT) gene variants predict response to bupropion therapy for tobacco dependence.

Biological psychiatry - 1 Jan 2007

Berrettini Wade H, Wileyto E Paul, Epstein Leonard, Restine Stephanie, Hawk Larry, Shields Peter, Niaura Ray, Lerman Caryn

Abstract excerpt

BACKGROUND: Although bupropion is efficacious for smoking cessation, only a minority of smokers are able to quit. Pharmacogenetic research may improve treatment outcomes through discovery of DNA sequences predictive of successful pharmacotherapy for subgroups of smokers. We investigated variants in the catechol-O-methyltransferase (COMT) gene in a smoking cessation trial of bupropion. METHODS: A double-blind,...

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Source

Identifiers

PMID: 16876132
DOI: 10.1016/j.biopsych.2006.04.030

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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