Article
Distinct perinatal features of the hyperpolarization-activated non-selective cation current I(h) in the rat cortical plate.
Neural development - 13 Jun 2012
Battefeld Arne, Rocha Nino, Stadler Konstantin, Bräuer Anja U, Strauss Ulf
Abstract excerpt
BACKGROUND: During neocortical development, multiple voltage- and ligand-gated ion channels are differentially expressed in neurons thereby shaping their intrinsic electrical properties. One of these voltage-gated ion channels, the hyperpolarization-activated cyclic nucleotide-gated (HCN) channel and its current I(h), is an important regulator of neuronal excitability. Thus far, studies on an early I(h)...
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