Article

The P2X7 receptor contributes to seizures and inflammation-driven long-lasting brain hyperexcitability following neonatal hypoxia in mice

2022-10-06

Abstract excerpt

<h4>Background: </h4> and Purpose Neonatal seizures are a clinical emergency. Current anti-seizure medications, however, fail to resolve seizures in ~50% of infants. The P2X7 receptor (P2X7R) is an important driver of inflammation and evidence suggest P2X7R contributing to seizures and epilepsy in adults. To date, however, no genetic proof has been provided to determine the contribution of the P2X7R to neonatal se...

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Literature Corpus work: f2d9526c-070a-5eba-8fef-3818c90fede1
DOI: 10.22541/au.166508305.54244816/v1

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