Article

Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice

2021-04-24

Abstract excerpt

<h4>ABSTRACT</h4> The development of the cerebral cortex relies on the controlled division of neural stem and progenitor cells. The requirement for precise spatiotemporal control of proliferation and cell fate places a high demand on the cell division machinery, and defective cell division can cause microcephaly and other brain malformations. Cell-extrinsic and intrinsic factors govern the capacity of cortical pr...

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Literature Corpus work: 10951490-0dd9-58bc-9cdf-62d5028e4f88
DOI: 10.1101/2021.04.24.441237

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