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Article

Developmental febrile seizures modulate hippocampal gene expression of hyperpolarization-activated channels in an isoform- and cell-specific manner.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jun 2002

Brewster Amy, Bender Roland A, Chen Yuncai, Dube Celine, Eghbal-Ahmadi Mariam, Baram Tallie Z

Abstract excerpt

Febrile seizures, in addition to being the most common seizure type of the developing human, may contribute to the generation of subsequent limbic epilepsy. Our previous work has demonstrated that prolonged experimental febrile seizures in the immature rat model increased hippocampal excitability long term, enhancing susceptibility to future seizures. The mechanisms for these profound proepileptogenic changes did...

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Share to Cyclic Nucleotide-Gated Cation Channels
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12040066
PMCID: PMC3372984

Genes

HCN2
CA1
CA3
HCN1
HCN4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Developmental febrile seizures modulate hippocampal gene expression of hyperpolarization-activated channels in an isoform- and cell-specific manner.PMID 12040066Read ↗

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