Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

AAV-Mediated CRISPRi and RNAi Based Gene Silencing in Mouse Hippocampal Neurons

4 Feb 2021

Abstract excerpt

Uncovering the physiological role of individual proteins that are part of the intricate process of cellular signaling is often a complex and challenging task. A straightforward strategy of studying a protein’s function is by manipulating the expression rate of its gene. In recent years, the Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)/Cas9-based technology was established as a powerful...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to RNA regulation and disease
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33557342
DOI: 10.3390/cells10020324

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

AAV-Mediated CRISPRi and RNAi Based Gene Silencing in Mouse Hippocampal NeuronsPMID 33557342Read ↗

An improved CRISPR/dCas9 interference tool for neuronal gene suppressionSemantic proximity Read ↗

CRISPR interference-based platform for multimodal genetic screens in human iPSC-derived neuronsSemantic proximity Read ↗

A versatile CRISPR toolbox to study neurological Ca <sub>V</sub> 3.2 channelopathies by promoter-mediated transcription controlSemantic proximity Read ↗

Editing the Neuronal Genome: a CRISPR View of Chromatin Regulation in Neuronal Development, Function, and Plasticity.Semantic proximity Read ↗

<i>In vivo</i> CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsySemantic proximity Read ↗

A Massively Parallel CRISPR-Based Screening Platform for Modifiers of Neuronal ActivitySemantic proximity Read ↗

Cell specific single viral vector CRISPR/Cas9 editing and genetically encoded tool delivery in the central and peripheral nervous systemsSemantic proximity Read ↗

<i>In vivo</i> silencing of regulatory elements using a single AAV-CRISPRi vectorSemantic proximity Read ↗

Genetic editing of primary human dorsal root ganglion neurons using CRISPR-Cas9Semantic proximity Read ↗

PV interneuron-targeted CRISPRa rescue of <i>SCN1A</i> haploinsufficiency in Dravet syndromeSemantic proximity Read ↗

CRISPR-mediated <i>Stxbp1</i> gene activation ameliorates epileptic and aggressive phenotypes in <i>Stxbp1</i> -haploinsufficient miceSemantic proximity Read ↗

Targeted Gene and Genome Editing Strategies for Epilepsy: Advances and Translational ChallengesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.