Article
The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.
The Journal of experimental medicine - 22 Sept 2014
Kovács Miklós, Németh Tamás, Jakus Zoltán, Sitaru Cassian, Simon Edina, Futosi Krisztina, Botz Bálint, Helyes Zsuzsanna, Lowell Clifford A, Mócsai Attila
Abstract excerpt
Although Src family kinases participate in leukocyte function in vitro, such as integrin signal transduction, their role in inflammation in vivo is poorly understood. We show that Src family kinases play a critical role in myeloid cell-mediated in vivo inflammatory reactions. Mice lacking the Src family kinases Hck, Fgr, and Lyn in the hematopoietic compartment were completely protected from autoantibody-induced...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.