Article
Functional Effect of the Mutations Similar to the Cleavage during Platelet Activation at Integrin β3 Cytoplasmic Tail when Expressed in Mouse Platelets.
PloS one - 1 Jan 2016
Shi Xiaofeng, Yang Jichun, Cui Xiongying, Huang Jiansong, Long Zhangbiao, Zhou Yulan, Liu Ping, Tao Lanlan, Ruan Zheng, Xiao Bing, Zhang Wei, Li Dongya, Dai Kesheng, Mao Jianhua, Xi Xiaodong
Abstract excerpt
Previous studies in Chinese hamster ovary cells showed that truncational mutations of β3 at sites of F754 and Y759 mimicking calpain cleavage regulate integrin signaling. The roles of the sequence from F754 to C-terminus and the conservative N756ITY759 motif in platelet function have yet to be elaborated. Mice expressing β3 with F754 and Y759 truncations, or NITY deletion (β3-ΔTNITYRGT, β3-ΔRGT, or β3-ΔNITY) were...
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