Article
Cytoplasmic Ape1 expression elevated by p53 aberration may predict survival and relapse in resected non-small cell lung cancer.
Annals of surgical oncology - 1 Dec 2013
Wu Heng-Hsiung, Chu Ya-Chiung, Wang Lee, Tsai Lung-Hung, Lee Ming-Ching, Chen Chi-Yi, Shieh Shwn-Huey, Cheng Ya-Wen, Lee Huei
Abstract excerpt
BACKGROUND: Subcellular localization of apurinic/apyrimidinic endonuclease-1/redox factor-1 (Ape1) has been demonstrated to promote lung tumor malignancy via NF-κB activation. We hypothesized that increased cytoplasmic Ape1 expression might cause NF-κB activation by p53 aberration, and result in poor outcome in non-small cell lung cancer (NSCLC). METHODS: Herein, knockdown of E6 or p53 and overexpression of E6...
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