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Article

Functional characterization of a promoter polymorphism in APE1/Ref-1 that contributes to reduced lung cancer susceptibility.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2009

Lu Juan, Zhang Shuyu, Chen Dan, Wang Huibo, Wu Wenting, Wang Xiaotian, Lei Yunping, Wang Jiucun, Qian Ji, Fan Weiwei, Hu Zhibin, Jin Li, Shen Hongbing, Huang Wei, Wei Qingyi, Lu Daru

Abstract excerpt

Apurinic/apyrimidinic endonuclease 1/redox effector factor-1 (APE1/Ref-1) is a ubiquitous multifunctional protein that possesses both DNA-repair and redox regulatory activities. Although it was originally identified as a DNA-repair enzyme, accumulating evidence supports a role of APE1/Ref-1 in tumor development. To investigate association between APE1/Ref-1 polymorphisms and lung cancer risk in Chinese...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19541747
DOI: 10.1096/fj.09-136549

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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