Article

Cytoplasmic APE1 promotes lung cancer aggressiveness and cisplatin resistance via the COX-2/Akt/β-catenin pathway

2022-06-01

Abstract excerpt

<h4>Background: </h4> Cisplatin is commonly used in lung cancer therapy, but cisplatin resistance in lung cancer cells remains an unsolved problem. Here, we report that cytoplasmic APE1 contributes to cisplatin resistance, cell proliferation and migration in lung cancer cells. Methods Immunofluorescence, western blot analysis, lentivirus transfection and scratch assays, and transwell migration and invasion assays...

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Literature Corpus work: aca897fd-3a32-554d-b3f5-5ee35959ddee
DOI: 10.21203/rs.3.rs-1620610/v1

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