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Cytoplasmic APE1 promotes lung cancer aggressiveness and cisplatin resistance via the COX-2/Akt/β-catenin signaling pathway

2020-09-23

Abstract excerpt

BACKGROUND Cisplatin is commonly used in lung cancer therapy, but cisplatin resistance in lung cancer cells remains an unsolved problem. Here, we report that cytoplasmic APE1 contributes to cisplatin resistance, cell proliferation and migration in lung cancer cells. METHODS Immunofluorescence, western blot analysis, lentivirus transfection and scratch assays, and transwell migration and invasion assays were carr...

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Literature Corpus work
1c9c2de9-cbb9-5125-9ff5-20d0a65aafb8
DOI
10.21203/rs.3.rs-78089/v1
Open publication

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Cytoplasmic APE1 promotes lung cancer aggressiveness and cisplatin resistance via the COX-2/Akt/β-catenin signaling pathwayDOI 10.21203/rs.3.rs-78089/v1
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