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Article

Nuclear exclusion of TET1 is associated with loss of 5-hydroxymethylcytosine in IDH1 wild-type gliomas.

The American journal of pathology - 1 Aug 2012

Müller Tim, Gessi Marco, Waha Anke, Isselstein Lukas Jan, Luxen Daniel, Freihoff Dorothee, Freihoff Johannes, Becker Albert, Simon Matthias, Hammes Jennifer, Denkhaus Dorota, zur Mühlen Anja, Pietsch Torsten, Waha Andreas

Abstract excerpt

The recent identification of isocitrate dehydrogenase 1 (IDH1) gene mutations in gliomas stimulated various studies to explore the molecular consequences and the clinical implications of such alterations. The Cancer Genome Atlas Research Network showed evidence for a CpG island methylator phenotype in glioblastomas that was associated with IDH1 mutations. These alterations were associated with the production of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22688054
DOI: 10.1016/j.ajpath.2012.04.017

Genes

IDH1
TET1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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