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Article

Insulator dysfunction and oncogene activation in IDH mutant gliomas.

Nature - 7 Jan 2016

Flavahan William A, Drier Yotam, Liau Brian B, Gillespie Shawn M, Venteicher Andrew S, Stemmer-Rachamimov Anat O, Suvà Mario L, Bernstein Bradley E

Abstract excerpt

Gain-of-function IDH mutations are initiating events that define major clinical and prognostic classes of gliomas. Mutant IDH protein produces a new onco-metabolite, 2-hydroxyglutarate, which interferes with iron-dependent hydroxylases, including the TET family of 5'-methylcytosine hydroxylases. TET enzymes catalyse a key step in the removal of DNA methylation. IDH mutant gliomas thus manifest a CpG island...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26700815
DOI: 10.1038/nature16490
PMCID: PMC4831574

Genes

CTCF
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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