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Article

Exome sequencing identifies frequent genomic loss of TET1 in IDH-wild-type glioblastoma.

Neoplasia (New York, N.Y.) - 1 Dec 2020

Stasik Sebastian, Juratli Tareq A, Petzold Andreas, Richter Sven, Zolal Amir, Schackert Gabriele, Dahl Andreas, Krex Dietmar, Thiede Christian

Abstract excerpt

Glioblastoma (GBM) is the most common and malignant brain tumor in adults. Genomic and epigenomic alterations of multiple cancer-driving genes are frequent in GBM. To identify molecular alterations associated with epigenetic aberrations, we performed whole exome sequencing-based analysis of DNA copy number variations in 55 adult patients with IDH-wild-type GBM. Beside mutations in common GBM driver genes such as...

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Identifiers

PMID: 33142244
DOI: 10.1016/j.neo.2020.10.010
PMCID: PMC7642757

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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